Why the study?
Does hyponatremia or hyperkalemia enhance ventricular conduction and rhythm disorders caused by moderate plasma bupivacaine concentrations in dogs?
Population
46 anesthetized, closed-chest dogs
Comparison
Bupivacaine combined with induced dilutional… vs Bupivacaine alone, 1.5% glycine alone, or KCl…
Design
Preclinical
Authors
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May worsen bupivacaine conduction slowing in dogs with hyponatremia/hyperkalemia; hypothesis-generating, should not change practice.
Does hyponatremia or hyperkalemia enhance ventricular conduction and rhythm disorders caused by moderate plasma bupivacaine concentrations in dogs?
Hyponatremia and hyperkalemia exacerbate the prolongation of ventricular conduction time and QRS duration caused by moderate concentrations of bupivacaine, increasing the risk of ventricular arrhythmias.
Timour et al. (1990) studied this question.
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