Why the study?
Does intravenous bupivacaine alter cardiac electrophysiology and hemodynamics in pentobarbital-anesthetized dogs?
Population
pentobarbital-anesthetized dogs
Design
Preclinical
Authors
Loading...
Bupivacaine >1000 ng/ml may impair conduction and inotropy in dogs; leaves open human safety thresholds.
Does intravenous bupivacaine alter cardiac electrophysiology and hemodynamics in pentobarbital-anesthetized dogs?
Bupivacaine at plasma levels around 2000 ng/ml alters cardiac electrophysiology and decreases left ventricular inotropy in dogs, potentially increasing susceptibility to reentrant arrhythmias.
Hotvedt et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: