Why the study?
Does the combination of bupivacaine and mild hypothermia increase ventricular conduction disturbances and arrhythmias in anesthetized dogs?
Population
Dogs anesthetized with thiopental-chloralose (3 groups, n=10-12 per group)
Comparison
Bupivacaine combined with mild hypothermia vs Bupivacaine alone and hypothermia alone
Design
Preclinical
Follow-up
Acute (during infusion and cooling)
Authors
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May warrant caution combining bupivacaine with hypothermia; leaves open human translation.
Does the combination of bupivacaine and mild hypothermia increase ventricular conduction disturbances and arrhythmias in anesthetized dogs?
Mild hypothermia significantly potentiates the proarrhythmic and conduction-delaying effects of bupivacaine in a canine model.
Freysz et al. (1989) studied this question.
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