Why the study?
What are the echocardiographic and hemodynamic effects of bupivacaine cardiotoxicity in anesthetized dogs?
Population
9 pentobarbital anesthetized dogs
Comparison
Bupivacaine injection vs Baseline (before bupivacaine injection)
Design
Preclinical
Follow-up
Acute (until asystole)
Authors
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Should not yet inform clinical management of bupivacaine toxicity; hypothesis-generating for human RV-focused interventions.
What are the echocardiographic and hemodynamic effects of bupivacaine cardiotoxicity in anesthetized dogs?
Echocardiography reveals that bupivacaine cardiotoxicity is characterized by profound right ventricular dilation, impaired systolic function, and significant hypotension in a canine model.
Coyle et al. (1994) studied this question.
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