December 1, 1984Anesthesia & Analgesia
Effects of Intravenous Bupivacaine on Cardiovascular Function and Plasma Catecholamine Levels in Humans
Why the study?
Does intravenous bupivacaine alter cardiovascular function and plasma catecholamine levels in normal subjects?
Population
8 normal subjects
Design
RCT, randomized, single-blind
Follow-up
3 hr
Authors
Discussion
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Member takes
Implication
Systemic bupivacaine may reduce cardiac output despite rising pressure; confirms direct hemodynamic effects in normal subjects.
Structured PICO
Does intravenous bupivacaine alter cardiovascular function and plasma catecholamine levels in normal subjects?
P
Population
8 normal subjects
I
Intervention
Intravenous infusion of bupivacaine (2 mg/min for 3 hr)
O
Outcome
Cardiovascular function (heart rate, mean arterial blood pressure, cardiac output) and endocrine metabolic parameters (plasma catecholamines, glucose, lactate, cortisol, free fatty acids)surrogate
Systemically administered bupivacaine causes positive chronotropic and arterial vasoconstrictive effects, likely through direct cardiovascular action rather than major catecholamine release.
Cite This Study
Hasselstrem et al. (1984) studied this question.