Why the study?
Does epinephrine reverse high-concentration bupivacaine-induced inhibition of sodium, L-type calcium, and transient outward potassium currents in ventricular myocytes of rats?
Population
Ventricular myocytes isolated from adult male Sprague-Dawley rats (250-300 g)
Comparison
Bupivacaine 100 μmol/L in combination with… vs Bupivacaine 100 μmol/L alone
Design
Preclinical
Authors
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Epinephrine may offer only partial reversal of bupivacaine cardiotoxicity; leaves open its role as sole rescue agent in humans.
Does epinephrine reverse high-concentration bupivacaine-induced inhibition of sodium, L-type calcium, and transient outward potassium currents in ventricular myocytes of rats?
Epinephrine reverses bupivacaine-induced inhibition of calcium and potassium channels but not sodium channels in rat ventricular myocytes, suggesting its limited efficacy as a sole agent for bupivacaine-induced cardiac toxicity.
Liu et al. (2015) studied this question.
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