Why the study?
Does R(+) bupivacaine cause greater cardiotoxicity than S(-) bupivacaine due to enantiomer-selective inhibition of L-type Ca2+ channels in isolated rat hearts and myocytes?
Population
Isolated rat hearts and isolated rat ventricular cells
Comparison
R bupivacaine at increasing concentrations vs S(-) bupivacaine at increasing concentrations
Design
Preclinical
Authors
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Rules out stereoselective ICa-L inhibition as driver of R(+) bupivacaine cardiotoxicity in rats; leaves open alternative mechanisms for study.
Does R(+) bupivacaine cause greater cardiotoxicity than S(-) bupivacaine due to enantiomer-selective inhibition of L-type Ca2+ channels in isolated rat hearts and myocytes?
The increased cardiotoxicity and arrhythmogenic effect of R(+) bupivacaine compared to S(-) bupivacaine is not explained by stereoselective inhibition of L-type Ca2+ channels.
Zapata‐Sudo et al. (2001) studied this question.
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