Why the study?
Does intravenous bupivacaine inhibit baroreflex control of heart rate in conscious rats?
Population
Conscious rats
Comparison
Rapid intravenous administration of bupivacaine vs Baseline (before bupivacaine administration)
Design
Preclinical
Follow-up
15 minutes
Authors
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Bupivacaine may blunt baroreflex sensitivity via vagal pathways in rats; leaves open human relevance and clinical impact.
Does intravenous bupivacaine inhibit baroreflex control of heart rate in conscious rats?
Intravenous bupivacaine inhibits baroreflex control of heart rate in conscious rats, primarily through vagal pathways.
Chang et al. (2000) studied this question.
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