Why the study?
Does thoracic epidural anaesthesia with bupivacaine reduce baroreflex sensitivity in patients under general anaesthesia?
Population
30 patients under general anaesthesia
Comparison
Thoracic epidural anaesthesia with bupivacaine… vs Control group
Design
RCT, randomly assigned
Authors
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Thoracic epidural bupivacaine impairs baroreflex sensitivity under general anesthesia; confirms sympathetic dependence and warrants close hemodynamic monitoring.
Does thoracic epidural anaesthesia with bupivacaine reduce baroreflex sensitivity in patients under general anaesthesia?
Thoracic epidural anaesthesia impairs the baroreflex-mediated heart rate response to decreases in arterial pressure, indicating dependence on sympathetic nervous system integrity.
Goertz et al. (1992) studied this question.
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