Why the study?
Does lidocaine or phenytoin improve bupivacaine-induced QRS prolongation in isolated rabbit hearts?
Population
24 isolated rabbit hearts retrogradely perfused in a nonrecirculating Langendorff apparatus
Comparison
Increasing concentrations of either lidocaine or… vs Saline added to 3 μM bupivacaine by 10-min-step…
Design
Preclinical
Follow-up
10-min steps
Authors
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May contraindicate lidocaine or phenytoin for bupivacaine cardiotoxicity; hypothesis-generating in rabbit hearts and requires clinical validation.
Does lidocaine or phenytoin improve bupivacaine-induced QRS prolongation in isolated rabbit hearts?
Lidocaine and phenytoin exacerbate rather than reverse bupivacaine-induced QRS prolongation in isolated rabbit hearts, suggesting they are contraindicated for bupivacaine cardiotoxicity.
Simon et al. (2002) studied this question.
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