Why the study?
Does lidocaine or phenytoin reduce bupivacaine-induced QRS prolongation in isolated rabbit hearts?
Population
24 isolated rabbit hearts retrogradely perfused in a nonrecirculating Langendorff apparatus
Comparison
Lidocaine or phenytoin in increasing… vs Saline added to 3 microM bupivacaine
Design
Preclinical
Follow-up
10-min steps
Authors
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May exacerbate bupivacaine cardiotoxicity in this model; leaves open clinical translation and requires prospective validation.
Does lidocaine or phenytoin reduce bupivacaine-induced QRS prolongation in isolated rabbit hearts?
Lidocaine and phenytoin exacerbate bupivacaine-induced QRS prolongation in isolated rabbit hearts, suggesting they should not be used for bupivacaine intoxication.
Simon et al. (2002) studied this question.
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