Why the study?
Does isoproterenol reverse bupivacaine-induced electrophysiologic toxicity in isolated rabbit hearts?
Population
8 isolated rabbit hearts
Comparison
Isoproterenol added to bupivacaine infusion vs Bupivacaine (1 microgram/mL) alone
Design
Preclinical
Authors
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Should not change management of bupivacaine toxicity; leaves open clinical translation pending human data.
Does isoproterenol reverse bupivacaine-induced electrophysiologic toxicity in isolated rabbit hearts?
Isoproterenol reverses bupivacaine-induced electrophysiologic abnormalities in an isolated rabbit heart model, suggesting potential therapeutic value for bupivacaine intoxication.
Lacombe et al. (1991) studied this question.
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