Key result
Insulin injection significantly increased survival (100% vs 50%, p=0.038) and reduced severe arrhythmias in rabbits with bupivacaine-induced cardiovascular collapse compared to saline.
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Animal data suggest insulin benefit in bupivacaine toxicity; hypothesis-generating and requires human studies before practice change.
Absolute Event Rate: 100% vs 50%
p-value: p=0.038
Choi et al. (2011) studied Bupivacaine-induced cardiovascular collapse (n=16). Regular insulin vs. 0.9% NaCl was evaluated on Survival (p=0.038). Insulin injection significantly increased survival (100% vs 50%, p=0.038) and reduced severe arrhythmias in rabbits with bupivacaine-induced cardiovascular collapse compared to saline.
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