Key result
Bupivacaine induced similar impairment in ventricular conduction in newborn and adult rabbit hearts, but newborn rabbits were approximately three times more sensitive to its effects on contractility.
Why the study?
Does bupivacaine have differential effects on ventricular conduction and contractility in newborn versus adult rabbit hearts?
Population
Isolated heart preparation from newborn and adult rabbits
Comparison
Step-increasing concentrations of bupivacaine vs Comparison between newborn and adult rabbit hearts
Design
Preclinical
Authors
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Hypothesis-generating in rabbits; leaves open whether neonatal bupivacaine dosing requires adjustment in humans.
Does bupivacaine have differential effects on ventricular conduction and contractility in newborn versus adult rabbit hearts?
In an isolated rabbit heart model, newborn hearts are significantly more sensitive to the negative inotropic effects of bupivacaine than adult hearts, despite similar effects on ventricular conduction.
Simon et al. (2004) studied Bupivacaine cardiotoxicity. Bupivacaine vs. Adult rabbit hearts (compared to newborn) was evaluated on QRS complex duration and first derivative of left ventricular pressure. Bupivacaine induced similar impairment in ventricular conduction in newborn and adult rabbit hearts, but newborn rabbits were approximately three times more sensitive to its effects on contractility.
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