Population
Isolated perfused heart of the rabbit (n=10 total; 6 in main experiment, 4 in additional experiment)
Design
Preclinical
Follow-up
20 min after cessation of lignocaine infusion
Authors
Loading...
QRS effects track central compartment levels in rabbit hearts; leaves open human PK-PD translation for lignocaine monitoring.
In isolated rabbit hearts, lignocaine's effect on QRS widening is closely related to the central compartment (vascular stream) rather than deep tissue accumulation.
Mazoit et al. (1990) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: