Key result
Bupivacaine decreased myofibrillar Ca2+ sensitivity in rat ventricular muscle, significantly shifting the midpoint of the pCa-tension relation (P<0.05).
Why the study?
Does bupivacaine decrease myofibrillar Ca2+ sensitivity in rat ventricular muscle?
Population
Rat ventricular muscle (isolated intact myocytes and Triton X-100-treated ventricular trabeculae)
Comparison
Bupivacaine (3, 10, and 100 microm) vs Absence of bupivacaine
Design
Preclinical
Authors
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May partly explain bupivacaine cardiodepression in rats; leaves open translation to human myocardium.
Does bupivacaine decrease myofibrillar Ca2+ sensitivity in rat ventricular muscle?
p-value: p=< 0.05
Bupivacaine decreases myofibrillar Ca2+ sensitivity in rat ventricular muscle, which may partly explain its in vivo cardiodepressant effect.
Mio et al. (2002) studied this question. Bupivacaine was evaluated on pCa-tension relation and maximal Ca2+-activated tension (p=< 0.05). Bupivacaine decreased myofibrillar Ca2+ sensitivity in rat ventricular muscle, significantly shifting the midpoint of the pCa-tension relation (P<0.05).
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