Key result
Bupivacaine caused irregular intracellular Ca2+ oscillations and eventual loss of oscillations in neonatal rat cardiomyocytes exposed to increased extracellular K+.
Why the study?
Does bupivacaine affect intracellular Ca2+ oscillations in neonatal rat cardiomyocytes differently than lidocaine under varying extracellular K+ concentrations?
Population
Neonatal rat cardiomyocytes
Design
Preclinical
Authors
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May implicate hyperkalemia in bupivacaine cardiotoxicity via Ca2+ dysregulation in neonatal models; leaves open clinical translation and reversal by divalent cations.
Does bupivacaine affect intracellular Ca2+ oscillations in neonatal rat cardiomyocytes differently than lidocaine under varying extracellular K+ concentrations?
Increased extracellular K+ may be an important component of bupivacaine cardiotoxicity, which can be reversed by increasing extracellular Mg2+ and Ca2+.
McCaslin et al. (2000) studied this question. Bupivacaine vs. Lidocaine was evaluated on Intracellular Ca2+ oscillations. Bupivacaine caused irregular intracellular Ca2+ oscillations and eventual loss of oscillations in neonatal rat cardiomyocytes exposed to increased extracellular K+.
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