Why the study?
Do different amide local anesthetics have varying electrophysiologic and hemodynamic cardiotoxic effects in an anesthetized dog model?
Population
Pentobarbital-anesthetized closed-chest dogs (5 groups)
Comparison
Intravenous administration of amide local… vs Comparison between different local anesthetics…
Design
Preclinical
Follow-up
Acute (e.g., 1 minute)
Authors
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Etidocaine causes severe hemodynamic collapse in canine models; hypothesis-generating for clinical cardiotoxicity risks and resuscitation challenges.
Do different amide local anesthetics have varying electrophysiologic and hemodynamic cardiotoxic effects in an anesthetized dog model?
Etidocaine and bupivacaine induce marked electrophysiologic and hemodynamic impairment in a canine model, potentially explaining the difficulty in resuscitating patients with cardiotoxicity from these agents.
Bruelle et al. (1996) studied this question.
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