Why the study?
What are the comparative electrophysiologic and hemodynamic effects of intravenous lidocaine, mepivacaine, etidocaine, and bupivacaine in anesthetized dogs?
Population
Pentobarbital-anesthetized closed-chest dogs in a cardiac electrophysiologic model (five groups)
Comparison
Intravenous administration of amide local… vs Baseline values and comparison between different…
Design
Preclinical
Follow-up
1 min (for acute hemodynamic changes)
Authors
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Etidocaine's hemodynamic collapse in dogs supports clinical caution with amide anesthetics; leaves open human translation and comparative toxicity data.
What are the comparative electrophysiologic and hemodynamic effects of intravenous lidocaine, mepivacaine, etidocaine, and bupivacaine in anesthetized dogs?
Etidocaine and bupivacaine induce severe combined electrophysiologic and hemodynamic impairment in dogs, which may explain the difficulty in resuscitating patients with cardiotoxicity from these agents.
Bruelle et al. (1996) studied this question.
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