Key result
Bupivacaine and etidocaine markedly increased ERP temporal dispersion (97.1 and 92.5 ms) and induced polymorphic ventricular tachycardia in 6 of 7 dogs each, unlike lidocaine.
Why the study?
Do different amide local anesthetics alter effective refractory period temporal dispersion and arrhythmogenicity in anesthetized dogs?
Population
32 pentobarbital-anesthetized adult mongrel dogs
Comparison
Intravenous administration of equipotent doses… vs Control period
Design
Preclinical
Authors
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Bupivacaine and etidocaine may increase arrhythmic risk versus lidocaine; leaves open translation to human anesthetic selection.
Do different amide local anesthetics alter effective refractory period temporal dispersion and arrhythmogenicity in anesthetized dogs?
The differential arrhythmogenicity of amide local anesthetics appears to be explained by the magnitude of their effects on effective refractory period temporal dispersion.
Gregory W. Kasten (1986) studied this question. bupivacaine, etidocaine, mepivacaine, and lidocaine vs. control period was evaluated on effective refractory period (ERP) temporal dispersion. Bupivacaine and etidocaine markedly increased ERP temporal dispersion (97.1 and 92.5 ms) and induced polymorphic ventricular tachycardia in 6 of 7 dogs each, unlike lidocaine.
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