Why the study?
Does ropivacaine modify action potential configuration and ion currents in isolated canine ventricular cardiomyocytes compared to bupivacaine?
Does ropivacaine modify action potential configuration and ion currents in isolated canine ventricular cardiomyocytes compared to bupivacaine?
Ropivacaine, similar to bupivacaine, modifies cardiac action potentials and blocks multiple ion currents at supratherapeutic concentrations, highlighting the risk of cardiac complications in overdose.
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Ropivacaine may signal overdose cardiotoxicity risk akin to bupivacaine; leaves open translation to human therapeutic concentrations.
Szabó et al. (2008) studied this question.
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