Why the study?
Does ropivacaine block cloned human cardiac K+ channels (hKv1.5)?
Population
Cloned human cardiac K+ channels (hKv1.5) stably transfected in Ltk cells
Comparison
Ropivacaine (100 microM) vs Control (baseline currents without ropivacaine)
Design
Preclinical
Authors
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Ropivacaine's hKv1.5 blockade may contribute to proarrhythmia risk; leaves open clinical relevance at therapeutic concentrations.
Does ropivacaine block cloned human cardiac K+ channels (hKv1.5)?
Ropivacaine acts as an open channel blocker of human cardiac hKv1.5 potassium channels, providing a mechanistic explanation for its ability to induce early afterdepolarizations.
Valenzuela et al. (1997) studied this question.
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