Why the study?
Does S(-)-bupivacaine affect Vmax and APD differently than R(+)-bupivacaine in guinea-pig papillary muscle?
Population
Guinea-pig isolated papillary muscles (from guinea-pigs 300-500g of either sex)
Comparison
S-bupivacaine and R-bupivacaine vs Control conditions
Design
Preclinical
Authors
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Hypothesis-generating for lower cardiotoxicity of S(-)-bupivacaine; leaves open clinical translation from guinea-pig models.
Does S(-)-bupivacaine affect Vmax and APD differently than R(+)-bupivacaine in guinea-pig papillary muscle?
S(-)-bupivacaine has less depressant effect on the maximal rate of depolarization and action potential duration in guinea-pig papillary muscle compared to R(+)-bupivacaine, which may explain its lower in vivo cardiotoxicity.
Vanhoutte et al. (1991) studied this question.
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