Why the study?
What are the cardiovascular effects of imipramine in intact dogs and isolated dog atria?
Population
18 mongrel dogs weighing 10-20 Kg (for isolated atria) and donor dogs weighing 8-16 Kg
Comparison
Imipramine continuous infusion vs Baseline/control levels before imipramine infusion
Design
Preclinical
Follow-up
up to 30 minutes of infusion
Authors
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Imipramine's dose-dependent effects in dogs should not alter clinical practice; leaves open human translation and safety studies.
What are the cardiovascular effects of imipramine in intact dogs and isolated dog atria?
Imipramine causes hypotension mainly due to peripheral vasodilation and suppresses baroceptive reflex mechanisms at high doses in a canine model.
Watanabe et al. (1981) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: