Why the study?
Does N-monomethyl L-arginine (L-NMMA) reduce blood flow responses during reactive hyperaemia in healthy human subjects?
Population
10 healthy subjects aged 19-34 years
Comparison
10 min intra-arterial infusion of 8 micromol… vs Matching placebo administered in random order
Design
RCT, Random order
Authors
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L-NMMA does not blunt reactive hyperaemia; challenges nitric oxide dependence and directs research toward alternative forearm vasodilator pathways.
Does N-monomethyl L-arginine (L-NMMA) reduce blood flow responses during reactive hyperaemia in healthy human subjects?
Nitric oxide production does not significantly contribute to vasodilatation during reactive hyperaemia in the human forearm.
Nugent et al. (1999) studied this question.
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