Key result
Nonalcoholic fatty liver disease was associated with a significantly higher risk of cardiac conduction defects compared to individuals without the disease (OR 5.17).
Why the study?
Cardiovascular disease commonly co-occurs with NAFLD, but the relationship between NAFLD and cardiac conduction defects has not been well studied.
Does nonalcoholic fatty liver disease increase cardiac conduction defects in adult patients?
Meta-Analysis (n=3,651)
Does nonalcoholic fatty liver disease increase cardiac conduction defects in adult patients?
Odds Ratio: 5.17 (95% CI 1.34–20.01)
p-value: p=0.02
Nonalcoholic fatty liver disease is associated with an approximately 5-fold increased risk of cardiac conduction defects, highlighting the need for cardiovascular awareness in this patient population.
BACKGROUND: Cardiovascular disease is a common comorbidity of patients with nonalcoholic fatty liver disease (NAFLD), particularly coronary artery disease and congestive heart failure. However, the relation between NAFLD and cardiac conduction defects has not been well studied. This systematic review and meta-analysis was conducted to identify all available studies on this association and summarize their results. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through June 2020 to identify studies that compared the risk of a cardiac conduction defect among patients with NAFLD versus those without. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. RESULTS: 96%). CONCLUSION: A significantly greater risk of cardiac conduction defects among patients with NAFLD was observed in this meta-analysis. How this risk should be managed in clinical practice requires further investigation.
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Karn Wijarnpreecha (2020) conducted a meta-analysis in Nonalcoholic fatty liver disease (n=3,651). Nonalcoholic fatty liver disease vs. Individuals without nonalcoholic fatty liver disease was evaluated on Cardiac conduction defect (OR 5.17, 95% CI 1.34-20.01, p=0.02). Nonalcoholic fatty liver disease was associated with a significantly higher risk of cardiac conduction defects compared to individuals without the disease (OR 5.17).
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