Key result
SCN5A variations were significantly associated with quantitative ECG traits in Black participants, explaining up to 2% of the variation (P<1.0×10(-4)).
Why the study?
Are SCN5A genetic variations associated with quantitative electrocardiographic traits in a black population?
Population
4,558 black subjects from the Jackson Heart Study who were genotyped, with association tests performed in…
Design
Cohort
Authors
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May inform arrhythmia risk in Black patients; extends SCN5A associations but remains hypothesis-generating.
Cohort (n=5,301)
Are SCN5A genetic variations associated with quantitative electrocardiographic traits in a black population?
p-value: p=<1.0×10(-4)
SCN5A genetic variations are significantly associated with quantitative ECG traits in individuals of African descent, potentially influencing susceptibility to arrhythmias.
Jeff et al. (2011) conducted a cohort in ECG traits (n=5,301). SCN5A variation was evaluated on Quantitative ECG traits (P, PR, QRS, QT, and QTc durations, heart rate, and P, QRS, and T axes) (p=<1.0×10(-4)). SCN5A variations were significantly associated with quantitative ECG traits in Black participants, explaining up to 2% of the variation (P<1.0×10(-4)).
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