Why the study?
Does short onset to balloon time or short door to balloon time reduce the composite of death and congestive heart failure in patients with STEMI undergoing primary PCI?
Population
3,391 patients with ST segment elevation myocardial infarction who had primary percutaneous coronary…
Comparison
Short onset to balloon time and short door to… vs Long onset to balloon time and long door to…
Design
Cohort
Follow-up
3 years
Key result
An onset to balloon time of <3 hours was associated with a lower risk of death and congestive heart failure compared to >3 hours (adjusted HR 0.70; 95% CI 0.56-0.88; P=0.002).
Authors
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Supports minimizing total ischemic time in STEMI; extends prior evidence but leaves door-to-balloon impact open in observational data.
Observational (n=3,391)
Yes
Does short onset to balloon time or short door to balloon time reduce the composite of death and congestive heart failure in patients with STEMI undergoing primary PCI?
Hazard Ratio: 0.7 (95% CI 0.56–0.88)
Absolute Event Rate: 13.5% vs 19.2%
p-value: p=0.002
Minimizing total ischemic time (onset to balloon) is critical for long-term outcomes in STEMI, as the benefit of rapid door-to-balloon times is primarily seen in patients who present early after symptom onset.
Shiomi et al. (2012) conducted an observational in ST segment elevation myocardial infarction (STEMI) (n=3,391). Onset to balloon time < 3 hours vs. Onset to balloon time > 3 hours was evaluated on Composite of death and congestive heart failure (adjusted HR 0.70, 95% CI 0.56-0.88, p=0.002). An onset to balloon time of <3 hours was associated with a lower risk of death and congestive heart failure compared to >3 hours (adjusted HR 0.70; 95% CI 0.56-0.88; P=0.002).