What question did this study set out to answer?

Investigate the cellular compartmentalization and biochemical pathway of fatty acid synthesis from acetate in human liver homogenates.

April 1, 1962Journal of Clinical InvestigationOpen Access

Fatty Acid Synthesis From Acetate by Human Liver Homogenate Fractions*

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Authors

WBW. BortzMax Planck Institut für Zellbiologie SAS. AbrahamTarget (United States)ICI.L. ChaikoffUniversity of California, Berkeley

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Implication

In vitro study demonstrates distinct extramitochondrial fatty acid synthesis in human liver tissue, highlighting separate enzymatic pathways from mitochondrial oxidation.

Key Points

Investigate the cellular compartmentalization and biochemical pathway of fatty acid synthesis from acetate in human liver homogenates.
Fractionated human liver homogenates to isolate extramitochondrial and mitochondrial cellular components.
Evaluated the biochemical dependence of fatty acid synthesis on specific metabolic cofactors, including malonyl-CoA and TPNH.
Fatty acid synthesis occurred in extramitochondrial compartments, functioning independently of mitochondrial fatty acid oxidation.
Acetate incorporation into fatty acids strictly required the formation and participation of malonyl-CoA and TPNH.

Cite This Study

Bortz et al. (1962) studied this question.

synapsesocial.com/papers/6a82e4548aa2f088808d6a31 https://doi.org/10.1172/jci104543

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Implication

In vitro study demonstrates distinct extramitochondrial fatty acid synthesis in human liver tissue, highlighting separate enzymatic pathways from mitochondrial oxidation.

Fatty Acid Synthesis From Acetate by Human Liver Homogenate Fractions*

Discussion

Member takes

Implication

Key Points

Cite This Study

Fatty Acid Synthesis From Acetate by Human Liver Homogenate Fractions*

Discussion

Member takes

Implication

Key Points

Cite This Study

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