Why the study?
Does an alternative serine protease pathway contribute to the rise in plasma Angiotensin II levels during exercise in healthy volunteers?
Population
n=6 healthy volunteers
Comparison
Experiment 1: Captopril 150 mg/day for 3 days… vs Experiment 1: Placebo; Experiment 2: Captopril…
Design
RCT, crossover, double-blind
Follow-up
acute (during and immediately after exercise)
Authors
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Serine protease inhibition attenuates exercise Ang II rise; confirms ACE-independent pathway in humans.
Does an alternative serine protease pathway contribute to the rise in plasma Angiotensin II levels during exercise in healthy volunteers?
This study demonstrates that an ACE-independent, serine protease-mediated pathway contributes to the generation of Angiotensin II during exercise in humans.
Miura et al. (1994) studied this question.
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