Key result
A novel Tl(+) flux assay demonstrated that fluoxetine inhibits mK(ATP) channels (IC50=2.4 micromol/L) and blocks cardioprotection triggered by ischemic preconditioning.
Population
Preclinical model for mitochondrial ATP-sensitive potassium channel (mK(ATP)) activity
Comparison
Novel thallium (Tl)-sensitive fluorophore… vs Classical mK channel osmotic swelling assay…
Design
Preclinical
Authors
Loading...
May blunt preconditioning in patients on fluoxetine; hypothesis-generating for mK(ATP) effects in human cardioprotection.
A novel Tl(+) flux assay demonstrates that fluoxetine inhibits mK(ATP) channels and blocks ischemic preconditioning-induced cardioprotection, which may have implications for patients on antidepressants.
Wojtovich et al. (2010) studied Ischemic preconditioning and cardioprotection. Fluoxetine was evaluated on mK(ATP) activity. A novel Tl(+) flux assay demonstrated that fluoxetine inhibits mK(ATP) channels (IC50=2.4 micromol/L) and blocks cardioprotection triggered by ischemic preconditioning.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: