Why the study?
Lower DVT and PE incidence post-TKA in Asians makes routine Western chemoprophylaxis protocols debatable, particularly given higher wound complications with LMWH compared to Aspirin.
Does LMWH compared to aspirin increase wound complications or reduce DVT/PE in patients undergoing primary total knee arthroplasty?
Observational (n=463)
Open-label
Non-randomized
No
Does LMWH compared to aspirin increase wound complications or reduce DVT/PE in patients undergoing primary total knee arthroplasty?
Absolute Event Rate: 33.9% vs 20.8%
p-value: p=0.004
In primary TKA patients, aspirin provides similar DVT/PE prophylaxis to LMWH but with significantly fewer bleeding and wound complications.
Aspirin may reduce wound complications versus LMWH in TKA without compromising VTE protection; leaves open confirmation by randomized trials.
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Reddy et al. (2022) conducted an observational in Primary unilateral total knee arthroplasty (n=463). Low molecular weight heparin (LMWH) vs. Aspirin 75 mg oral once a day was evaluated on Incidence of wound soakage (p=0.004).
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