Key result
An imbalance between the sympathetic and parasympathetic nervous systems is proposed as a unifying mechanism underlying the hallmarks of aging, offering potential therapeutic targets such as vagus nerve stimulation.
Why the study?
Understanding age-dependent changes is essential for promoting healthy aging and longevity.
Design
Review
Authors
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Autonomic imbalance may drive aging phenotypes; hypothesis-generating for parasympathetic-targeted interventions before clinical adoption.
This perspective proposes that age-related sympathetic-parasympathetic deregulation drives the hallmarks of aging, suggesting vagus nerve stimulation as a potential anti-aging therapy.
Errico et al. (2025) conducted a review in Aging. Sympathetic-parasympathetic system imbalance was evaluated. An imbalance between the sympathetic and parasympathetic nervous systems is proposed as a unifying mechanism underlying the hallmarks of aging, offering potential therapeutic targets such as vagus nerve stimulation.
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