Key result
Autonomic disorders in old age stem from intrinsic neurobiological changes, organ degeneration, and secondary diseases.
Why the study?
Distinguishing autonomic disorders due to normal aging from those caused by diseases in old age is challenging and requires better understanding of neurobiological changes.
Design
Review of neurobiological changes in the autonomic nervous system with aging and disease
Authors
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May inform evaluation of autonomic symptoms in older adults; leaves open mechanistic targets for prospective interventional studies.
This review highlights the neurobiological changes in the autonomic nervous system associated with aging and disease, emphasizing the role of neuroplasticity and neurotrophic factors.
Kenneth J. Collins (1997) conducted a review in Autonomic disorders in old age. Autonomic disorders in old age are attributed to intrinsic neurobiological changes, degenerative changes in effector organs, and secondary involvement of the autonomic nervous system in disease.
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