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July 28, 2021Open Access

Aging is associated with cardiac autonomic nerve fiber depletion and reduced cardiac and circulating BDNF levels.

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Key result

Physiological aging in rats is linked to reduced cardiac autonomic nerve density and lower BDNF.

  • P<0.05
  • n=21

Why the study?

Whether and how neurotrophic factors and their downstream signaling are involved in cardiac aging remained unclear.

Population

Young and old rats

Comparison

Serum from old rats vs serum from young rats

Authors

AEAndrea EliaTemple UniversityACAlessandro CannavòFederico II University HospitalGGGiuseppina GambinoUniversity of Naples Federico II

Discussion

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Implication

Does not change clinical practice in cardiac aging; hypothesis-generating for BDNF-targeted human studies.

Structured PICO

P
Population
Young and old rats (in vitro cell culture model using rat serum)
I
Intervention
Serum from old rats
C
Comparator
Serum from young rats
O
Outcome
Neuronal sprouting (crystal violet assay), GAP-43 and BDNF protein levelssurrogate

Main Result

p-value: p=<0.05

Physiological aging impairs autonomic nervous system structure and function, partially driven by reduced BDNF levels.

Limitations

  • Did not monitor left ventricular function in the rat model.
  • Serum withdrawn from senescent rats can lack or miss other factors in addition to neurotrophins.
  • Cannot exclude that abnormalities in the expression/release of other neurotrophic factors, such as NT3 and NT4, may also be at play in the aged myocardium.
  • The causes of BDNF depletion deserve further in-depth investigation.

Cite This Study

Elia et al. (2021) studied Physiological aging (n=21). Aging vs. Young age (3 months) was evaluated on Cardiac autonomic nerve fiber density and BDNF protein levels (p=<0.05). Physiological aging in rats is associated with a marked reduction in cardiac autonomic nerve fiber density and decreased cardiac and circulating BDNF levels.

synapsesocial.com/papers/6a15ca96a4734e8e604e710dhttps://doi.org/10.11909/j.issn.1671-5411.2021.07.009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts2006 · 142 citations
  2. 2Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice2013 · 70 citations
  3. 3Vascular Endothelial Growth Factor Blockade Prevents the Beneficial Effects of β-Blocker Therapy on Cardiac Function, Angiogenesis, and Remodeling in Heart Failure2013 · 54 citations
  4. 4Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter2017 · 13 citations
  5. 5BDNF-mediated enhancement of inflammation and injury in the aging heart2005 · 61 citations