Key result
Rear footpad administration of porcine myocardial myosin reliably induced experimental autoimmune myocarditis with 100% morbidity and 20-44% mortality, whereas subcutaneous immunization did not.
Population
Male young Lewis rats
Comparison
Porcine myocardial myosin immunization via rear… vs Sham group
Design
Preclinical
Follow-up
21 days
Authors
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May facilitate standardized EAM induction in rats with reduced distress; leaves open human applicability pending validation.
Rear footpad administration of lower doses of myosin reliably induces experimental autoimmune myocarditis in rats with lower mortality and animal distress compared to higher doses or subcutaneous administration.
Schmerler et al. (2014) studied experimental autoimmune myocarditis. porcine myocardial myosin via rear footpads vs. subcutaneous immunization or sham was evaluated on mortality and morbidity (inflammatory infiltrates). Rear footpad administration of porcine myocardial myosin reliably induced experimental autoimmune myocarditis with 100% morbidity and 20-44% mortality, whereas subcutaneous immunization did not.
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