Key result
Fetuses with tetralogy of Fallot had significantly higher rates of abnormalities in 7 cardiac parameters, including pulmonary artery peak systolic velocity, compared to healthy controls (P < .001).
Why the study?
Does quantitative assessment of fetal hemodynamics and biometrics differentiate fetuses with tetralogy of Fallot from healthy fetuses?
Population
220 fetuses in the second trimester, including 20 with a diagnosis of classic tetralogy of Fallot and 200…
Comparison
Quantitative assessment of 16 cardiac parameters vs Healthy fetuses
Design
Case-control
Authors
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May support fetal echo parameters for TOF differentiation; hypothesis-generating, requires prospective validation.
Case-Control (n=220)
Does quantitative assessment of fetal hemodynamics and biometrics differentiate fetuses with tetralogy of Fallot from healthy fetuses?
p-value: p=< .001
Quantitative assessment of fetal hemodynamics and valve sizes, particularly pulmonary artery peak systolic velocity and aortic-to-pulmonary valve diameter ratio, can aid in confirming the diagnosis of fetal tetralogy of Fallot.
Jatavan et al. (2016) conducted a case-control in Tetralogy of Fallot (n=220). Tetralogy of Fallot vs. Healthy fetuses was evaluated on Rates of abnormalities in 16 cardiac parameters (p=< .001). Fetuses with tetralogy of Fallot had significantly higher rates of abnormalities in 7 cardiac parameters, including pulmonary artery peak systolic velocity, compared to healthy controls (P < .001).
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