Key result
The risk of a new cardiovascular disease event among acute coronary syndrome survivors declined significantly over time (HR 0.969 per calendar year; 95% CI 0.960-0.977), though prognosis remains worse than the general population.
Why the study?
Has the long-term prognosis of acute coronary syndrome survivors improved over time compared to a healthy population?
Population
13,336 patients aged ≥35 years who had their first acute coronary syndrome during 1993–2011 and survived the…
Comparison
Occurrence of first acute coronary syndrome… vs Apparently healthy population with the same age…
Design
Cohort
Follow-up
1 year and 3 years
Authors
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Improved ACS survivor prognosis supports sustained secondary prevention; leaves open whether residual excess risk versus the general population can be eliminated.
Observational (n=13,336)
Yes
Has the long-term prognosis of acute coronary syndrome survivors improved over time compared to a healthy population?
Hazard Ratio: 0.969 (95% CI 0.96–0.977)
p-value: p=4.63 × 10−13
While the long-term prognosis of acute coronary syndrome survivors has improved significantly over an 18-year period, their risk of cardiovascular events and mortality remains substantially higher than that of the general population.
Piironen et al. (2016) conducted an observational in acute coronary syndrome (n=13,336). Calendar year vs. Earlier calendar years / General population was evaluated on New cardiovascular disease event at three years (HR 0.969, 95% CI 0.960-0.977, p=4.63 × 10−13). The risk of a new cardiovascular disease event among acute coronary syndrome survivors declined significantly over time (HR 0.969 per calendar year; 95% CI 0.960-0.977), though prognosis remains worse than the general population.
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