December 1, 1996Planta Medica

Procyanidines fromVitis viniferaSeeds Protect Rabbit Heart from Ischemia/Reperfusion Injury: Antioxidant Intervention and/or Iron and Copper Sequestering Ability

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Population

Isolated rabbit heart Langendorff preparation subjected to 40 minutes of low flow (1 ml/min) ischemia

Comparison

Infusion of highly purified, high molecular… vs Untreated control and allopurinol

Design

Preclinical

Authors

RFRoberto Maffei FacinoUniversity of Milan MCM. CariniUniversity of Milan GAGiancarlo AldiniUniversity of Milan

Discussion

Member takes

Implication

Does not support clinical use; leaves open translation of procyanidine cardioprotection to human ischemia/reperfusion injury.

Structured PICO

Population

Isolated rabbit heart Langendorff preparation subjected to 40 minutes of low flow (1 ml/min) ischemia

Intervention

Infusion of highly purified, high molecular weight fraction of oligomeric procyanidines from Vitis vinifera seeds (100 or 200 micrograms/ml)

Comparator

Untreated control (implied) and allopurinol (20 micrograms/ml)

Outcome

Myocardial reperfusion injury parameters including ventricular contracture (LVEDP), coronary perfusion pressure (CPP), cardiac mechanical performance, 6-keto-PGF1 alpha release, and rhythm irregularitysurrogate

Procyanidines from Vitis vinifera seeds protect isolated rabbit hearts from ischemia/reperfusion injury through antioxidant and iron/copper sequestering mechanisms.

Cite This Study

Facino et al. (1996) studied this question.

synapsesocial.com/papers/6a82fb0e6a8af808ea7d562e https://doi.org/10.1055/s-2006-957956

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Procyanidines fromVitis viniferaSeeds Protect Rabbit Heart from Ischemia/Reperfusion Injury: Antioxidant Intervention and/or Iron and Copper Sequestering Ability

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Procyanidines fromVitis viniferaSeeds Protect Rabbit Heart from Ischemia/Reperfusion Injury: Antioxidant Intervention and/or Iron and Copper Sequestering Ability

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider