Key result
Mechanical stimulation and Propranolol administration in Wistar rats resulted in heart rate and blood pressure changing in the same direction (r2 = 0.72 and 0.62, respectively; p < 0.05).
Population
Wistar rats
Design
Preclinical
Authors
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May inform mechanistic models of hypertension-stiffening interplay; leaves open human translation or practice change.
Effect estimate: r2 = 0.72 and 0.62
p-value: p=< 0.05
The 'oscillating spring' analogy for arterial radial vibration can explain hemodynamic changes in response to stimulation, suggesting a mechanism for the bidirectional relation between hypertension and arterial stiffening.
Hsiu et al. (2008) studied Animal model (Wistar rats). Mechanical stimulation or Propranolol was evaluated on Relationship between heart rate (HR) and blood pressure (BP) (r2 = 0.72 and 0.62, p=< 0.05). Mechanical stimulation and Propranolol administration in Wistar rats resulted in heart rate and blood pressure changing in the same direction (r2 = 0.72 and 0.62, respectively; p < 0.05).
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