Key result
Optimal control strategies for treatment and vaccination in a hand-foot-mouth disease model minimized the cost of intervention and the number of infected people in numerical simulations.
The study provides a mathematical model demonstrating optimal control strategies for hand-foot-mouth disease using treatment and vaccination.
Mathematical HFMD modeling is hypothesis-generating; requires prospective validation before informing practice.
We build and study the transmission dynamics of a hand-foot-mouth disease model with vaccination. The reproduction number is given, the existence of equilibria is obtained, and the global stability of disease-free equilibrium is proved by constructing the Lyapunov function. We also apply optimal control theory to the hand-foot-mouth disease model. The treatment and vaccination interventions are considered in the hand-foot-mouth disease model, and the optimal control strategies based on minimizing the cost of intervention and minimizing the number of the infected people are given. Numerical results show the usefulness of the optimization strategies.
No takes yet. Share an insight, caveat, or question.
Tan et al. (2018) studied Hand-foot-mouth disease. Treatment and vaccination interventions was evaluated. Optimal control strategies for treatment and vaccination in a hand-foot-mouth disease model minimized the cost of intervention and the number of infected people in numerical simulations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: