Key result
NMR spectroscopy using 59Co and 2H/1H allows for accurate measurement and continuous monitoring of intracellular water volumes, providing insights into cardiac muscle physiology.
NMR spectroscopy using 59Co and 2H/1H nuclei allows for non-invasive monitoring of intracellular water volumes, providing insights into cardiac muscle physiology.
Determination of the intracellular water volumes using NMR spectroscopy was performed using the NMR-visible nuclei: 59Co and 2H or 1H. Accurate measurement of intracellular water in cell suspensions and perfused organs is an important physiological parameter in the context of electrolyte homeostasis and energy metabolism, in particular when these parameters are monitored by non-invasive NMR spectroscopy. Furthermore, repeated or continuous monitoring of intracellular water provided significant insights into the physiology of cardiac muscle and sarcolemmal membrane permeability and integrity.
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Askenasy et al. (2005) conducted a review in Cardiac muscle physiology. NMR spectroscopy (59Co and 2H/1H) was evaluated on Intracellular water volumes. NMR spectroscopy using 59Co and 2H/1H allows for accurate measurement and continuous monitoring of intracellular water volumes, providing insights into cardiac muscle physiology.
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