Key result
The rs1799983 polymorphism in the NOS3 gene was significantly associated with chronic kidney disease of non-traditional etiology in Mexican patients (OR 0.397; 95% CI 0.192-0.817; p=0.006).
Why the study?
Chronic kidney disease of uncertain or non-traditional etiology is not associated with traditional risk factors, prompting investigation into whether NOS3 gene polymorphisms are associated with the disease.
Are NOS3 gene polymorphisms associated with Chronic Kidney Disease of uncertain or non-traditional etiology in Mexican patients?
Population
105 patients with CKDnT and 90 controls in Mexico
Comparison
NOS3 polymorphisms rs2070744, 4b/a, and rs1799983 in CKDnT vs controls
Design
Case-control study
Authors
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Supports further investigation of NOS3 variants in non-traditional CKD; should not yet influence clinical decisions in Mexican patients.
Case-Control (n=195)
Are NOS3 gene polymorphisms associated with Chronic Kidney Disease of uncertain or non-traditional etiology in Mexican patients?
Odds Ratio: 0.397 (95% CI 0.192–0.817)
p-value: p=0.006
The rs1799983 polymorphism in the NOS3 gene is associated with Chronic Kidney Disease of uncertain or non-traditional etiology in the Mexican population.
Marín-Medina et al. (2023) conducted a case-control in Chronic Kidney Disease of uncertain or non-traditional etiology (CKDnT) (n=195). NOS3 gene polymorphisms (rs2070744, 4b/a, rs1799983) vs. Controls without CKDnT was evaluated on Association with CKDnT (OR 0.397, 95% CI 0.192-0.817, p=0.006). The rs1799983 polymorphism in the NOS3 gene was significantly associated with chronic kidney disease of non-traditional etiology in Mexican patients (OR 0.397; 95% CI 0.192-0.817; p=0.006).
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