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January 1, 2013Kidney & Blood Pressure ResearchOpen Access

NOS3 894G>T Polymorphism is Associated With Progression of Kidney Disease and Cardiovascular Morbidity in Type 2 Diabetic Patients: NOS3 as a Modifier Gene for Diabetic Nephropathy?

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Why the study?

Is the NOS3 894G>T polymorphism associated with progression of diabetic nephropathy and cardiovascular events in patients with type 2 diabetes?

Population

311 subjects with type 2 diabetes and defined stage of diabetic nephropathy

Comparison

NOS3 894G>T polymorphism vs Reference genotype (implied wild-type)

Design

Cohort

Follow-up

median 38 months

Authors

KKKatarína KuricováMasaryk UniversityVTVeronika TanhäuserováMasaryk UniversityLPLukáš PácalMasaryk University

Discussion

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Member takes

Implication

May aid T2D risk stratification but should not change practice; leaves open prospective validation of NOS3 genotyping.

Structured PICO

Is the NOS3 894G>T polymorphism associated with progression of diabetic nephropathy and cardiovascular events in patients with type 2 diabetes?

P
Population
311 subjects with type 2 diabetes and defined stage of diabetic nephropathy
I
Intervention
NOS3 894G>T polymorphism (894GT and 894TT genotypes)
C
Comparator
Reference genotype (implied wild-type)
O
Outcome
Progression of diabetic nephropathy, major cardiovascular event, and all-cause mortalityhard clinical

The NOS3 894G>T polymorphism may serve as a genetic marker for the progression of diabetic nephropathy and increased risk of major cardiovascular events in patients with type 2 diabetes.

Cite This Study

Kuricová et al. (2013) studied this question.

synapsesocial.com/papers/6a9129535f49dca04d2e4c4chttps://doi.org/10.1159/000355757
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Also Consider

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  4. 4Endothelial Nitric Oxide Synthase as a Potential Susceptibility Gene in the Pathogenesis of Emphysema in α 1-Antitrypsin Deficiency1999 · 71 citations
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