Key result
Prothrombin gene mutation G20210A prevalence varied from 0 to 15.9% among global ethnic groups, with higher rates observed in thromboembolism-affected cohorts compared with unaffected cohorts.
Systematic Review (n=61,876)
Yes
The prevalence of the prothrombin G20210A mutation varies significantly by ethnicity globally, which may guide targeted screening for hereditary thrombophilia in female populations.
Supports ethnicity-specific screening for prothrombin G20210A in thromboembolism patients; extends global prevalence data for risk stratification.
Distribution of hereditary thrombophilic gene mutations differs globally. Prothrombin gene mutation G20210A is a common prothrombotic single-nucleotide polymorphism. In this systematic review, we provide a comprehensive report of the prevalence of prothrombin G20210A across the globe. Databases [Pubmed, Web of Science, Embase] were interrogated from their inception through December 2015 for articles reporting prothrombin G20210A prevalence rates and ethnicity. Prevalence rates were organized by continent and ethnoracial ancestry. A total of 113 articles were included with a total 61 876 participants tested for prothrombin G20210A. Reported prevalence rates varied from 0 to 15.9% among ethnic groups, with higher rates seen in the thromboembolism affected cohort compared with the unaffected cohort. Carrier rate distribution is supported by known historical migration patterns of global populations. This review of prothrombin G20210A prevalence may guide resourceful screening for identification of hereditary thrombophilia in female populations of interest with hypercoagulable states.
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Dziadosz et al. (2016) conducted a systematic review in Hereditary thrombophilia (n=61,876). Prothrombin gene mutation G20210A vs. Unaffected cohort was evaluated on Prevalence rates of prothrombin G20210A. Prothrombin gene mutation G20210A prevalence varied from 0 to 15.9% among global ethnic groups, with higher rates observed in thromboembolism-affected cohorts compared with unaffected cohorts.
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