What question did this study set out to answer?

To re-evaluate the risk of thromboembolism associated with oral contraceptive use after controlling for six predisposing factors in the control population.

August 1, 1979American Journal of Epidemiology

Increased Risk of Thrombosis Due to Oral Contraceptives: A Further Report1

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Authors

MMMaureen G. MaguirePenn Presbyterian Medical Center JTJames TonasciaUniversity of Maryland, Baltimore PSPhilip E. SartwellMassachusetts Department of Public Health

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Implication

Case-control study demonstrates elevated thrombosis risk from oral contraceptives in predisposed and non-predisposed women, highlighting persistent dangers across diagnostic groups.

Key Points

To re-evaluate the risk of thromboembolism associated with oral contraceptive use after controlling for six predisposing factors in the control population.
Analyzed data from a case-control study of 461 cases and 1,302 controls individually matched on age, race, marital status, hospital, and admission date.
Evaluated the effect of six predisposing factors using matched set analysis and multivariable logistic regression.
Assessed relative risks across four diagnostic categories: venous thrombosis alone, pulmonary embolism alone, both combined, and myocardial infarction.
Adjusting for predisposing factors revised the estimated relative risk from 7.2 to 4.7 in idiopathic cases and increased it from 1.2 to 2.2 in predisposed cases.
Relative risk estimates exceeded 1.0 across all four diagnostic categories for both predisposed and non-predisposed groups.
Relative risk estimates did not vary significantly by age or smoking status.

Cite This Study

Maguire et al. (1979) studied this question.

synapsesocial.com/papers/6a82feb928b8a62be998fb5b https://doi.org/10.1093/oxfordjournals.aje.a112803

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Implication

Case-control study demonstrates elevated thrombosis risk from oral contraceptives in predisposed and non-predisposed women, highlighting persistent dangers across diagnostic groups.

Increased Risk of Thrombosis Due to Oral Contraceptives: A Further Report1

Discussion

Member takes

Implication

Key Points

Cite This Study

Increased Risk of Thrombosis Due to Oral Contraceptives: A Further Report1

Discussion

Member takes

Implication

Key Points

Cite This Study

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