Why the study?
Does enoxaparin reduce the incidence of deep vein thrombosis in patients undergoing major knee surgery?
Population
131 consecutive patients undergoing knee arthroplasty or tibial osteotomy at four participating hospitals.
Comparison
Enoxaparin 30 mg subcutaneously every 12 hours… vs Identical-appearing placebo, started the morning…
Design
RCT, Randomized, Double-blind
Follow-up
Up to 14 days
Authors
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Supports routine post-operative enoxaparin prophylaxis after major knee surgery; confirms LMWH efficacy in high-risk orthopedic RCTs.
Does enoxaparin reduce the incidence of deep vein thrombosis in patients undergoing major knee surgery?
A fixed-dose regimen of enoxaparin started post-operatively significantly reduces the frequency of deep vein thrombosis after major knee surgery without increasing bleeding risk.
Leclerc et al. (1992) studied this question.
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