June 27, 2000Circulation

Active Remodeling of the Coronary Arterial Lesions in the Late Phase of Kawasaki Disease

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Population

7 children with Kawasaki disease, 9 children with no coronary disease, and 3 adults with atherosclerosis.

Design

Cross-sectional

Authors

ASAtsuko SuzukiTokyo University of Pharmacy and Life Sciences SMSachiko Miyagawa‐TomitaYamazaki College of Animal Health Technology KKKeiko KomatsuTokai University

Discussion

Member takes

Implication

Distinct growth factor patterns in Kawasaki disease lesions may guide future therapies; leaves open clinical translation pending prospective studies.

Structured PICO

Population

7 children with Kawasaki disease, 9 children with no coronary disease, and 3 adults with atherosclerosis (total n=19).

Comparator

Children with no coronary disease (n=9) and adults with atherosclerosis (n=3).

Outcome

Immunohistochemical expression of vascular growth factors (TGF-beta1, PDGF-A, bFGF, VEGF) and their receptors in coronary artery specimens.surrogate

Active remodeling of coronary artery lesions in Kawasaki disease involves luxuriant intimal proliferation and neoangiogenesis driven by vascular growth factors, a process distinct from adult atherosclerosis.

Cite This Study

Suzuki et al. (2000) studied this question.

synapsesocial.com/papers/6a8304b8103ff40a2293c2ae https://doi.org/10.1161/01.cir.101.25.2935

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Implication

Distinct growth factor patterns in Kawasaki disease lesions may guide future therapies; leaves open clinical translation pending prospective studies.

Active Remodeling of the Coronary Arterial Lesions in the Late Phase of Kawasaki Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Active Remodeling of the Coronary Arterial Lesions in the Late Phase of Kawasaki Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider