Key result
Aortic valve replacement with Carpentier-Edwards Perimount Magna and Magna Ease bioprostheses resulted in zero cases of severe prosthesis-patient mismatch across all risk groups.
Why the study?
Does aortic valve replacement with Carpentier-Edwards Perimount Magna and Magna Ease bioprostheses reduce the incidence of prosthesis-patient mismatch in patients with severe aortic stenosis?
Cohort (n=282)
No
Does aortic valve replacement with Carpentier-Edwards Perimount Magna and Magna Ease bioprostheses reduce the incidence of prosthesis-patient mismatch in patients with severe aortic stenosis?
The Carpentier-Edwards Perimount Magna and Magna Ease bioprostheses provide excellent hemodynamics and effectively prevent severe prosthesis-patient mismatch even in patients at high risk due to small aortic annuli.
These valves were associated with no severe PPM; leaves open need for RCTs before guiding valve selection in small annuli.
BACKGROUND: Prosthesis-patient mismatch (PPM) is associated with increased mid-term and long-term mortality rates after aortic valve replacement (AVR). This study aimed to evaluate the efficacy of the Carpentier-Edwards Perimount Magna and Magna Ease (CEPMs) aortic bioprostheses to reduce the incidence of PPM. METHODS AND RESULTS: among the LR, MR, and HR groups, respectively), the corresponding transvalvular mean pressure gradients (13.0±5.5, 12.3±4.0, 12.7±5.3 mmHg) and regression rates of the left ventricular mass (29.8%, 28.7%, 28.9%) were similar among groups. CONCLUSIONS: CEPMs provide low surgical risk and reduce the risks of PPM, even in HR patients, with excellent hemodynamics.
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Kume et al. (2017) conducted a cohort in Severe aortic stenosis (n=282). Carpentier-Edwards Perimount Magna and Magna Ease (CEPMs) bioprostheses vs. Low, medium, and high risk groups for prosthesis-patient mismatch based on BSA/AnnD ratio was evaluated on Incidence of severe prosthesis-patient mismatch (EOAI <0.65 cm2/m2). Aortic valve replacement with Carpentier-Edwards Perimount Magna and Magna Ease bioprostheses resulted in zero cases of severe prosthesis-patient mismatch across all risk groups.
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