Key result
Prolonged elevation of neurohormones in left ventricular dysfunction becomes directly toxic to the heart, accelerating apoptosis, myocyte hypertrophy, and interstitial fibrosis.
Describes the pathophysiological mechanisms of neurohormonal activation in left ventricular dysfunction.
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Explains benefits of neurohormonal blockade in LV dysfunction; confirms mechanisms but leaves open optimal targets for trials.
Kenneth L. Baughman (2002) conducted a review in Left ventricular dysfunction. B-Type Natriuretic Peptide was evaluated. Prolonged elevation of neurohormones in left ventricular dysfunction becomes directly toxic to the heart, accelerating apoptosis, myocyte hypertrophy, and interstitial fibrosis.
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